What is it about?
Exposed to the nanosecond pulsed electric field (nsPEF), biological cells can be stretched in the direction parallel to the electric field direction. A multiphysics model to investigate electrodeformation of a spherical cell with double-layered plasma membrane accounting for both electroporation and dielectric relaxation of the membrane is proposed, and the typical influential factors and indicators for electroporation and electrodeformation, are probed via the above multiphysics model under the action of unipolar and bipolar nsPEFs.
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Why is it important?
For the first time, a multiphysics model to investigate electrodeformation of a spherical cell with double-layered plasma membrane accounting for both electroporation and dielectric relaxation of the membrane is proposed.
Perspectives
Our model can reflect the temporal evolution of electroporation and electrodeformation procedure more accurately, which is instructive to exert the nsPEF in biochemical experiments and clinical applications.
Fei Guo
Chongqing University of Posts and Telecommunications
Read the Original
This page is a summary of: Multiphysics analysis of nsPEF induced electrodeformation in a dispersive cell model, Frontiers in Human Neuroscience, February 2021, American Institute of Physics,
DOI: 10.1063/5.0038772.
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