What is it about?

New solid forms of the anthelmintic fenbendazole are being used to improve release and anthelmintic efficacy. The use of analysis of crystal structures that were obtained on the synchrotron PXRD, Computational Methods and in vivo study explains the molecular reasons for the improvement in physicochemical properties

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Why is it important?

This is important because cocrystal scientists typically do not study biological properties. In this work, we make direct correlations between anthelmintic efficacy and crystal structure.


Use of these systems as an alternative to the commercial form to improve pharmaceutical properties, repurpose for cancer treatment and circumvent existing patents

Nikita Vasilev
Institute of Solution Chemistry of RAS

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This page is a summary of: Structural features, dissolution performance and anthelmintic efficacy of multicomponent solid forms of fenbendazole with maleic and oxalic acids, CrystEngComm, January 2023, Royal Society of Chemistry,
DOI: 10.1039/d2ce01644c.
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