What is it about?
The fusion of Cas9 nikase and cytidine deaminase is developed for C to T conversion in the genome of S. aureus.
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Why is it important?
The method can be used for gene inactivation by generating a premature stop codon with a high efficiency and without sacrificating transformation efficiency or using repair templates.
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This page is a summary of: Highly efficient base editing in Staphylococcus aureus using an engineered CRISPR RNA-guided cytidine deaminase, Chemical Science, January 2018, Royal Society of Chemistry,
DOI: 10.1039/c8sc00637g.
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