Modulation of the stability of i-motif structures using an acyclic threoninol cytidine derivative

Sonia Pérez-Rentero, Raimundo Gargallo, Carlos González, Ramon Eritja
  • RSC Advances, January 2015, Royal Society of Chemistry
  • DOI: 10.1039/c5ra10096h

The effect of a cytidine derivative on the stability of intramolecular i-motifs was investigated.

What is it about?

i-motif structures are unusual structures of DNA in cytosine-rich sequences. They are very stable at pH 4 but they unfold to random coil structures at pH 7. For these reasons they have been used to build pH sensors or pH-responsive nanomachines. In the paper we studied the effect in stability and pH-mediated transitions of i-motif structures carrying modified cytosine derivatives.

Why is it important?

The novel acyclic cytosine derivatives changes the stability and the pH range of stable i-motif structures opening the possibility of having structures that unfolds at different pH ranges.

Perspectives

Ramon Eritja
CSIC

This publication has led to our group to study other cytosine derivatives in a similar context finding novel derivatives that stabilize i-motif at neutral pHs. I-motif structures are fun to study as they are nicely observed by UV and CD spectroscopies.

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http://dx.doi.org/10.1039/c5ra10096h

The following have contributed to this page: Ramon Eritja

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