The effect of a cytidine derivative on the stability of intramolecular i-motifs was investigated.
What is it about?
i-motif structures are unusual structures of DNA in cytosine-rich sequences. They are very stable at pH 4 but they unfold to random coil structures at pH 7. For these reasons they have been used to build pH sensors or pH-responsive nanomachines. In the paper we studied the effect in stability and pH-mediated transitions of i-motif structures carrying modified cytosine derivatives.
Why is it important?
The novel acyclic cytosine derivatives changes the stability and the pH range of stable i-motif structures opening the possibility of having structures that unfolds at different pH ranges.
The following have contributed to this page: Ramon Eritja