What is it about?
Trifluoromethyl disulfides were prepared in a simple way without extremely hazardous CF3SCl or CF3SSCF3.
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Why is it important?
The method is suitable for non-specialized laboratories, and a structurally diverse thiols are suitable substrates for this transformation. A considerable number of trifluoromethyl disulfides were effectively prepared for the first time.
Perspectives
In spite of acidic reaction conditions, several acid-labile functional groups were tolerated. Some biologically interesting and rarely used thiols were succesfully transformed into trifluoromethyl disulfides.
Professor Marjan Jereb
University of Ljubljana
Read the Original
This page is a summary of: Electrophilic trifluoromethylthiolation of thiols with trifluoromethanesulfenamide, RSC Advances, January 2015, Royal Society of Chemistry,
DOI: 10.1039/c5ra07316b.
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