What is it about?
We have synthesized a homobasic DNA in the crystal state by adopting topochemical Azide Alkyne Cycloaddition (TAAC) reaction. This synthesis does not require solvents, catalysts etc.
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Why is it important?
This is the first topochemical synthesis of a DNA analog wherein phosphodiesters are replaced by triazole motifs. This is important as the synthesis does not involve the use of solvents, catalysts or other activators.
Perspectives
This is the first solid-state synthesis of DNA analog. This paper illustrates the power of supramolecular chemistry approach to solve complex chemical problems.
Kana Sureshan
Indian Institute of Science Education and Research Thiruvananthapuram
Read the Original
This page is a summary of: The topochemical synthesis of triazole-linked homobasic DNA, Chemical Communications, January 2016, Royal Society of Chemistry,
DOI: 10.1039/c5cc08834h.
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