Intein based bioprocessing of peptides as an alternative route to SPPS strategy

What is it about?

To overcome the shortcomings of peptide chemical synthesis, this paper presents an intein based auto-cleavage strategy for sustainable bioproduction of peptide based products. Bioprocess for a synthetic AMP was established by the above strategy and associated operating costs and environmental impact assessment compared with respect to the well established SPPS method. The article also presents how HPLC and calorimetric methods can be used as PAT tools for bioproduction of such peptides.

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Why is it important?

Peptide based products are in high demand within the Healthcare market. This study shows that the difficulty in scaling up peptide synthesis through SPPS methodology can be overcome by successful implementation of intein-based peptide bioprocessing platforms, thereby opening the way for an economical supply of therapeutic peptides at large scale.