Syntheses of quinazolinones from 2-iodobenzamides and enaminones via copper-catalyzed domino reactions

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Why is it important?

The enaminones, readily accessible through condensation reactions of 1,3-diketones and N-sources, provide an equivalent of unstable imine in which we believe it is a useful synthon in the synthesis of N-containing heterocylics. 3-Aminocyclohex-2-enone, especially, undergoes our copper-catalyzed domino process in which ketone functionality remains intact as a long carbon chain pendant.