Asn-Trp dipeptides improve the oxidative stress and learning dysfunctions

What is it about?

The NW dipeptide can be obtained from computer-aided pepsin simulated hydrolysis of dioscorin, the yam (Dioscorea spp.) tuber storage protein.

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Why is it important?

The present results showed that 40 mg kg-1 NW or carnosine intervention for 4 weeks can attenuate the oxidative stress induced by daily D-galactose subcutaneous injection for 8 weeks. However, only 40 mg NW kg-1 (NW40)intervention could improve spatial memory and learning dysfunctions in which the GSH content and ORAC activity in the brain tissues of NW40 intervention might pass threshold levels to reflect in part the correlations of improvement in Gal-induced aging and learning dysfunctions.