Polyphenol-rich apple (Malus domestica L.) peel extract attenuates arsenic trioxide induced cardiotoxicity in H9c2 cells via its antioxidant activity

Vadavanath Prabhakaran Vineetha, Seetharaman Girija, Rema Sreenivasan Soumya, Kozhiparambil Gopalan Raghu
  • Food & Function, January 2014, Royal Society of Chemistry
  • DOI: 10.1039/c3fo60470e

Polyphenol rich apple peel protect H9c2 cells from arsenic trioxide

What is it about?

The present publication deals with novel finding of reversal of toxicity of arsenic trioxide in H9c2 cells mediated via antioxidant potential of polyphenol present in peel. For this both in vitro cell free and cell based experiments had been employed to evaluate its antioxidant potential. Arsenic trioxide down-regulated innate antioxidant system in H9c2 cells while peel extract was able to keep innate antioxidant system intact even in presence of arsenic trioxide.

Why is it important?

This is a novel report on beneficial properties of apple peel for protection of heart of a cancer patient on chemotherapy.

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http://dx.doi.org/10.1039/c3fo60470e

The following have contributed to this page: Raghu KG, Vineetha V P, and soumya RS