What is it about?

a unified synthetic route to the chiral framework of the 19-epi-BE-43547 series was developed.

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Why is it important?

Studies revealed that BE-43547 A2 and Rakicidin A have shown significantly enhanced cytotoxicity against hypoxic cancer cells when compared to a series of well-established toxic compounds including Taxol.


A short and enantioselective synthesis of the 19-epi-BE-43547 A2 chiral framework has been achieved in a high yield.

Dr. Kranthi Kumar Ramagonolla
Harvard University

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This page is a summary of: Toward the synthesis of the hypoxia selective anticancer agent BE-43547 A2, Organic & Biomolecular Chemistry, January 2021, Royal Society of Chemistry,
DOI: 10.1039/d1ob01824h.
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