What is it about?
Siblings and even cousins cannot be treated as independent measurements on supposed epigenetic effects on grandparents. Analysis either has to take place at the level of the grandparents or using a hierarchical model that allows for dependence.
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Why is it important?
Shows that mixed models will probably be needed for epidemiological epigenetic studies.
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This page is a summary of: Epigenetics or ephemeral genetics?, European Journal of Human Genetics, July 2006, Springer Science + Business Media,
DOI: 10.1038/sj.ejhg.5201683.
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