What is it about?
Osteocytes are the mechanosensory cells that control bone adaptation. Here we sort out the magnitudes and modes of strains that cause osteocytes to increase the transcription of genes that support bone formation and decrease the transcription of genes that support bone resorption.
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Why is it important?
The role of bone in human health is underappreciated. Structurally, bone supports locomotion - that is mobility - which is essential to maintaining health. We are also learning that bone has endocrine functions and affects the normal function of other organ systems. Since bone is continually subjected to mechanical loads, it is impossible to understand its biology in the absence of mechanics.
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This page is a summary of: Differential gene expression in trabecular bone osteocytes is related to the local strain and strain gradient, Scientific Reports, May 2025, Springer Science + Business Media,
DOI: 10.1038/s41598-025-00214-z.
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