Small Molecules Attenuate the Interplay between Conformational Fluctuations, Early Oligomerization and Amyloidosis of Alpha Synuclein

Sumanta Ghosh, Amrita Kundu, Krishnananda Chattopadhyay
  • Scientific Reports, April 2018, Springer Science + Business Media
  • DOI: 10.1038/s41598-018-23718-3

Aggregation of Alpha Synuclein In Vitro and Inside Cells

What is it about?

The influence of several small molecules and amino acids on the early and late stage of alpha synuclein aggregation has been investigated using spectroscopy at the conventional and single molecule resolution. Arginine was found to inhibit the formation of amyloid formation by inducing a conformational change in the monomeric protein. In contrast, another amino acid glutamate facilitates amyloid fibril formation by facilitating the generation of small molecule oligomers.

Why is it important?

The result may have implication in developing therapeutic molecules against Parkinson's Disease.

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http://dx.doi.org/10.1038/s41598-018-23718-3

The following have contributed to this page: Krishnananda Chattopadhyay