What is it about?
PNPLA3 mutation involved in fatty liver disease development disrupts PPAR gamma signaling via JNK and regulates aquaporin 3 in HSC
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Why is it important?
PPAR gamma agonists could restore normal PPAR gamma signaling and aquaporin 3 levels in HSC contributing to their deactivation in fibrosis
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This page is a summary of: AQP3 is regulated by PPARγ and JNK in hepatic stellate cells carrying PNPLA3 I148M, Scientific Reports, November 2017, Nature,
DOI: 10.1038/s41598-017-14557-9.
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