What is it about?
only 10% of protein-protein interactions (PPIs) are known today. But, PPIs are very important for many studies in both molecular biology and systems biology. We have computationally discovered some hitherto unknown PPIs, which have been found to be highly accurate after evaluations with both experimental and computational means. Here, we present novel predicted PPIs, along with previously known PPIs, of about 100 genes associated with Schizophrenia.
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Why is it important?
Each new predicted PPI is a new biological hypothesis that can be tested and translated by biologists to advance schizophrenia (SZ) biology. There are more than five hundred novel PPIs! These PPIs also show hitherto unknown interconnections of SZ genes to relevant pathways. It also shows drug-protein interaction which highlights drugs that target multiple SZ genes or their interactors, offering a shortlist that may be studied further for potentially repurposing the drugs to treat SZ.
Perspectives
This work is especially important to me because it is the culmination of various algorithms and applications I developed with my students through the BRAINS grant of NIMH, whose goal was "Discovery of Mental Health Interactome". We not only developed algorithms for discovery of those PPIs, but also developed web applications and visualizations that make it really convenient for biologists to access and use this information. For example, the web-site (originally called 'Wiki-Pi' and for Schizophrenia it's called Schizo-PI, and 'LENS') as well as the visualizations we presented in high-res images (which may be printed as posters). We hope these predicted PPIs will be translated to advances in biology.
Madhavi K Ganapathiraju
University of Pittsburgh
Read the Original
This page is a summary of: Schizophrenia interactome with 504 novel protein–protein interactions, Schizophrenia, April 2016, Nature,
DOI: 10.1038/npjschz.2016.12.
You can read the full text:
Resources
Protein-Protein Interactions with Annotations about Functions, Pathways, Diseases, etc
The protein-protein interactions (PPIs) of all human genes, as well as novel predicted (high-accuracy) PPIs of schizophrenia genes, are made available online. Users can search not only by gene, but with additional conditions, e.g. "PPIs where a schizophrenia protein interacts with a protein involved in immunity". The website is designed so that biologists can search intuitively based on biological concepts. Each PPI is shown with annotations of the two proteins side-by-side conveniently - Gene Ontology, functions, pathways, disease and GWAS associations are shown side by side.
LENS: Network and enrichment analysis of gene sets
The website allows users to carry out network analysis of gene sets. We recently updated PPIs used by LENS to include novel PPIs described in this manuscript.
Contributors
The following have contributed to this page
