What is it about?

We used a technique called nanoLC MS/MS to determine the tear proteins dysregulated in dry eye. We found that a small set of tear proteins is correlated to dry eye severity.

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Why is it important?

These proteins can be used as biomarkers to monitor the progress of treatment in dry eye.


ROC analysis shows that a limited 4 panel protein may also be useful in dry eye.

Prof Louis Tong
National University of Singapore

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This page is a summary of: Identification of Tear Fluid Biomarkers in Dry Eye Syndrome Using iTRAQ Quantitative Proteomics, Journal of Proteome Research, September 2009, American Chemical Society (ACS), DOI: 10.1021/pr900686s.
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