What is it about?
The mAb was co-administered with HAVN1 peptide via intravenous administration to enhance brain depositions of the mAN in animal models.
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Why is it important?
This is very important because it is difficult to deliver proteins such antibodies across the BBB.
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This page is a summary of: Selective Uptake of Macromolecules to the Brain in Microfluidics and Animal Models Using the HAVN1 Peptide as a Blood-Brain Barrier Modulator, Molecular Pharmaceutics, February 2024, American Chemical Society (ACS),
DOI: 10.1021/acs.molpharmaceut.3c00775.
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