What is it about?

We have found that resistance to an antibiotic that imposes a large fitness cost on the bacteria impedes their ability to evolve resistance to other antibiotics. However, selecting the appropriate first antibiotic is key.

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Why is it important?

Antibiotic resistance has become a global healthcare crisis, threatening our access to modern healthcare. Our study showcases how we can use laboratory evolutions to understand the evolutionary trade-offs associated with antibiotic resistance, and exploit them to slow down evolution.

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This page is a summary of: Fitness Costs of Antibiotic Resistance Impede the Evolution of Resistance to Other Antibiotics, ACS Infectious Diseases, September 2023, American Chemical Society (ACS),
DOI: 10.1021/acsinfecdis.3c00156.
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