What is it about?
Optimizing precursor supply for cost-efficient production of acetyl-Coenzyme A derived biofuels and biochemicals by yeast
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Why is it important?
Many chemical compounds whose production by modern biotechnology is intensively investigated, ranging from life-saving drugs to aviation fuels, use acetyl-Coenzyme A, a key intermediate in metabolism, as a precursor. Efficient conversion of sugars into acetyl-CoA is therefore of key importance for economically and environmentally sustainable processes. This review paper critically analyses and discusses various strategies to make the production of acetyl-CoA in yeast more efficient.
Perspectives
A manuscript close to my heart and one of the final products of an inspiring 4-year collaboration with PhD students Barbara Kozak and Harmen van Rossum. Central carbon metabolism in yeast continues to be a stimulating research subject!
Prof Jack T Pronk
Technische Universiteit Delft
Read the Original
This page is a summary of: Engineering cytosolic acetyl-coenzyme A supply in Saccharomyces cerevisiae: Pathway stoichiometry, free-energy conservation and redox-cofactor balancing, Metabolic Engineering, July 2016, Elsevier,
DOI: 10.1016/j.ymben.2016.03.006.
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