Pyronaridine shows in vitro synergy with rifampicin against M. tuberculosis.
What is it about?
We repurposed the antimalarial pyronaridine as an anti tubercular as it showed synergy with Rifampicin in vitro.
Why is it important?
We proposed that pyronaridine may target the same protein as Rifampicin in Mtb, namely RNA polymerase. We present various data to show pyronaridine also has activity on its own but is markedly more active alongside Rifampicin.
The following have contributed to this page: Dr Sean Ekins