What is it about?
Nuclear shape contributes to gene organization and expression in cells. This study is focused on the regulator of the actin nucleoskeleton, mDia2. This allows the investigation of nuclear actin without affecting cytoplasmic actin. Knockdown of mDia2 disrupts the actin‐lamin nucleoskeleton. This results in the release of mesenchymal stem cells from their stem state and leads to differentiation.
Featured Image
Photo by National Cancer Institute on Unsplash
Why is it important?
This study demonstrates that the structural arrangement of the nucleo-skeleton is important in stem cell lineage commitment. Understanding MSC commitment is important for the identification of therapeutic targets to treat diverse disorders such as osteoporosis and obesity.
Perspectives
It is critical to understand not only the forces that promote MSC differentiation but also those that maintain MSC in an undifferentiated state.
Dr Maya Styner
University of North Carolina at Chapel Hill, Department of Medicine, Division of Endocrinology
Read the Original
This page is a summary of: Knockdown of formin mDia2 alters lamin B1 levels and increases osteogenesis in stem cells, Stem Cells, November 2019, Wiley, DOI: 10.1002/stem.3098.
You can read the full text:
Contributors
The following have contributed to this page
