What is it about?
This study tests whether an extract from Jacquez grape wine can protect human skin cells from UVB‑induced damage in a laboratory model. Using a three‑dimensional human epidermis, the authors evaluated cell viability, inflammatory mediators, oxidative damage to lipids and proteins, and glutathione‑based redox balance after UVB exposure.
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Why is it important?
UVB radiation increases reactive oxygen species in skin, triggering inflammation and oxidative damage. The extract—rich in proanthocyanidins with smaller amounts of anthocyanins and hydroxycinnamic acids—reduced markers of oxidative stress and inflammation in vitro, supporting interest in plant‑derived antioxidants for skin photoprotection research.
Perspectives
The work is strictly in vitro and uses a reconstructed epidermis model, which cannot capture systemic or long‑term effects in humans. Future steps would require formulation studies, skin penetration assessment, and in vivo or clinical investigations before any real‑world application.
Prof. Antonio Speciale
University of Messina
Read the Original
This page is a summary of: In vitro protective effect of a Jacquez grapes wine extract on UVB-induced skin damage, Toxicology in Vitro, December 2006, Elsevier,
DOI: 10.1016/j.tiv.2006.06.005.
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