What is it about?
Discusses various sources of variation in observed response in clinical trials: between patient, within patient and patient-by treatment interaction. Considers which of these sources different types of designs (e.g. parallel, crossover, n-of-1 etc) are capable of identifying.
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Why is it important?
Carefully considers the role of replication in identifying variation in observed response.
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This page is a summary of: Interpreting patient treatment response in analgesic clinical trials: Implications for genotyping, phenotyping, and personalized pain treatment, Pain, March 2014, Wolters Kluwer Health,
DOI: 10.1016/j.pain.2013.09.019.
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