What is it about?
We investigated in the present study whether intraperitoneal (i.p.) application of inosine (Ino; 500 and 1000 mg/kg), guanosine (Guo; 20 and 50 mg/kg), uridine (Urd; 500 and 1000 mg/kg), GABAA receptor agonist muscimol (1 and 3 mg/kg), GABAA receptor antagonist bicuculline (2 and 4 mg/kg), non-selective Ado receptor antagonist theophylline (5 and 10 mg/kg) and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo (a,d) cyclohepten-5,10-imine maleate (MK-801, 0.0625 and 0.1250 mg/kg) alone and in combination have modulatory effects on absence epileptic activity in absence epileptic Wistar Albino Glaxo Rijswijk (WAG/Rij) rats. We found that Guo decreased the number of spike-wave discharges (SWDs) whereas Ino increased it dose-dependently. We strengthened that Urd can decrease absence epileptic activity.
Featured Image
Why is it important?
Our results suggest that Guo, Urd and their analogues could be potentially effective drugs for treatment of human absence epilepsy.
Perspectives
Our results imply that Guo, Urd and their analogues may be useful, effective and safe antiepileptic drugs in the treatment of human absence epilepsy because Guo and Urd are well tolerated drugs with only minor toxic potential as demonstrated previously. The long-lasting absence epileptic activity decreasing effect of a single dose of Urd in the present study and in our previous study strengthened the usability of Urd as promising antiepileptic drugs.
Dr Zsolt Kovacs
Eötvös Loránd University
Read the Original
This page is a summary of: Absence epileptic activity changing effects of non-adenosine nucleoside inosine, guanosine and uridine in Wistar Albino Glaxo Rijswijk rats, Neuroscience, August 2015, Elsevier,
DOI: 10.1016/j.neuroscience.2015.05.054.
You can read the full text:
Resources
Contributors
The following have contributed to this page
