Acetylcholinesterase inhibition in the basolateral amygdala plays a key role in the induction of status epilepticus after soman exposure

What is it about?

We provide evidence that the amygdala has a much higher concentration of acetylcholinesterase (AChE) than many other seizurogenic brain regions. We also find that if AChE isn't completely inhibited in the amygdala, there will be no seizures or subsequent pathology.

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Why is it important?

This is important because we provide evidence that the amygdala is a necessary brain region for nerve-agent induced seizures. If AChE is not fully inhibited by a nerve agent in the BLA, seizures and subsequent behavioral and pathological deficits will not occur.