Viability, metabolic activity and immunomodulation assays on MSCs-coated meshes

What is it about?

Here we hypothe-size that Mesenchymal Stem Cells (MSCs) could be a useful tool tofavor the biocompatibility of material. The aims of this work wereto optimize the coating of surgical meshes with MSCs, to analyzethein vitroimmunomodulatory potential of MSCs-coated meshesand to determine their safety and feasibility in a murine model.

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Why is it important?

Our results indicated that MSCs-coated surgical meshes canbe easily cryopreserved and used as an ‘off the shelf’ product.They fulfill the safety aspects, exerting anin vitroandin vivoimmunomodulation which is mediated by a macrophage polar-ization towards an anti-inflammatory phenotype.Concluding, the combined usage of surgical meshes with MSCsfulfills the safety requirements for a future clinical application, pro-viding an anti-inflammatory environment that could reduce theinflammatory processes commonly observed after surgical meshimplantation