evolution of LXR, FXR, VDR, PXR and CAR
What is it about?
This review describes the evolution of the LXR, FXR, VDR, PXR and CAR nuclear hormone receptors. These are key transcription factors that regulate gene expression. Ligands for these receptors cover a whole array of endogenous and exogenous compounds and there is extensive overlap in the ligand selectivity as well as transcriptional regulation networks. We have used an array of computational and experimental approaches to probe the evolution of these receptors.
Why is it important?
These nuclear receptors are important for regulating drug metabolizing enzymes and transporters and therefore impact exposure of drugs. Many of these receptors are quite flexible and therefore are quite promiscuous. We have proposed using a ligand based modeling approach to understand evolution across species.
The following have contributed to this page: Dr Sean Ekins