What is it about?
Blocking the lacrimal punctum is an effective treatment in dry eye. However, retaining tear fluid may also result in the retention of proinflammatory molecules, so we performed a study to evaluate changes in tear protein at baseline and at 3 weeks after punctal occlusion.
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Why is it important?
We find that baseline Schirmer (whether it is above or below 5 mm) can determine the profile of tear protein change. Patients with less than 5 mm will benefit more from punctal occlusion since the inflammatory proteins will decrease and the lacrimal supportive proteins will increase.
Perspectives
Punctal occlusion is one common therapy for dry eye in clinics. These findings are important in personalised medicine, because they allow for patient selection in dry eye.
Prof Louis Tong
National University of Singapore
Read the Original
This page is a summary of: Effects of punctal occlusion on global tear proteins in patients with dry eye, The Ocular Surface, April 2017, Elsevier,
DOI: 10.1016/j.jtos.2017.04.002.
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