What is it about?
The small-molecule metabolome profile gives an instant snapshot of cellular activities. Here we examine the whole-joint metabolome after ACL-rupture injury in mice. Injury affects the abundance of many metabolites within 1 hour. New in this study is the observation that many metabolite changes require the activation of early response genes.
Featured Image
Why is it important?
Preventing the activation of early response genes after injury mostly restored the metabolomics profile to its uninjured state. Also, this divides the metabolites into two main categories: those metabolites that require early response gene activation, and those that do not.
Perspectives
It was great to collaborate with the June lab and their long-standing interest in how small-molecule metabolites affect joint health.
Professor Dominik R Haudenschild
Houston Methodist
Read the Original
This page is a summary of: Inhibition of early response genes prevents changes in global joint metabolomic profiles in mouse post-traumatic osteoarthritis, Osteoarthritis and Cartilage, March 2019, Elsevier,
DOI: 10.1016/j.joca.2018.11.006.
You can read the full text:
Contributors
The following have contributed to this page
