What is it about?
This study tested whether phenolic compounds from persimmon fruit (Diospyros kaki) could ease intestinal inflammation and help prevent colon cancer. In mice with chemically induced colitis, persimmon extract reduced visible gut damage, diarrhea, bleeding, and key markers of inflammation (COX-2 and iNOS). In the lab, the same extract slowed the growth and invasion of human colon cancer cells. Interestingly, while persimmon phenolics did not block gelatinase enzymes (MMP-2 and MMP-9), which often drive tissue damage and cancer spread, they still showed strong protective and anti-proliferative effects. These results suggest persimmon may support gut health through multiple mechanisms.
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Why is it important?
Inflammatory bowel diseases increase the risk of colorectal cancer, a major global health burden. Current drugs are costly and can cause side effects, making safe, food-based strategies attractive. This work highlights persimmon phenolics as promising candidates to both reduce gut inflammation and slow cancer-related changes. It underscores the potential of common fruits as functional foods or nutraceuticals to complement medical treatment.
Perspectives
What I find remarkable here is how an everyday fruit, often overlooked outside its cultural traditions, shows real potential in tackling two serious conditions—colitis and colorectal cancer. For me, this research embodies the idea that diet is not only nourishment but also a source of active compounds with measurable impact on disease. It points to a future where simple dietary choices might work hand in hand with medicine to prevent or ease chronic illness.
Dr. Rosa Direito
Universidade de Lisboa
Read the Original
This page is a summary of: Dyospiros kaki phenolics inhibit colitis and colon cancer cell proliferation, but not gelatinase activities, The Journal of Nutritional Biochemistry, August 2017, Elsevier,
DOI: 10.1016/j.jnutbio.2017.03.002.
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