What is it about?
The pathogenesis of non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) is likely due to the interaction between a deranged metabolic milieu of insulin resistance and local mediators of liver inflammation and fibrosis. This study provides in vivo support for a possible link between deranged metabolism in the adipose tissue and activation of hepatic macrophages in patients with NAFLD, most likely in response to free fatty acid overflow and independent of obesity and diabetes.
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Why is it important?
The study provides better understanding of this cross-talk between different tissues and metabolism for a better understanding of transition from simple steatosis to NASH with inflammation and fibrosis
Perspectives
Liver macrophages represent an attractive therapeutic target, but it is necessary to consider the potential role of adipose tissue IR in their activation in order to obtain a prolonged and sustainable effect on liver damage in NASH.
Clinical Chair Professor Henning Gronbaek
Aarhus Universitet
Read the Original
This page is a summary of: Crosstalk between adipose tissue insulin resistance and liver macrophages in Non Alcoholic Fatty Liver Disease, Journal of Hepatology, July 2019, Elsevier,
DOI: 10.1016/j.jhep.2019.06.031.
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