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• UPLC-QTOF-MSE combined with multivariate statistical analyzes were applied to investigate the metabolomic profiles of the Phyllanthus spp. • The SPE methodology was attested by 1H NMR analysis which shows the reductions of free carbohydrates. • It was possible to identify 33 possible biomarkers. Some of these markers were supposedly correlated with cytotoxic activity. • The SPE samples showed greater in vitro cytotoxicity than the crude extracts, against the tumor cell lines tested.

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This page is a summary of: UPLC-HRMS and NMR applied in the evaluation of solid-phase extraction methods as a rational strategy of dereplication of Phyllanthus spp. aiming at the discovery of cytotoxic metabolites, Journal of Chromatography B, April 2019, Elsevier,
DOI: 10.1016/j.jchromb.2019.04.029.
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