What is it about?
To investigate the association between G-protein β3 (GNB3) subunit gene 825C/T polymorphism and vasculogenic ED (VED).
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Why is it important?
Penile arterial insufficiency is one of the most common causes of erectile dysfunction (ED). Atherosclerotic occlusive disease can decrease arterial flow to the corpus cavernosum sinusoidal spaces, thus impairing penile tumescence. Common risk factors associated with general atherosclerosis include hypertension, hyperlipidemia, diabetes mellitus, and cigarette smoking. The 825T allele is associated with increased signal transduction . This polymorphism has been shown to be associated with hypertension, therosclerosis, obesity, and insulin resistance. Total cholesterol is significantly higher in subjects with the T allele. In a pilot study, Sperling et al. reported that homozygous 825T allele carriers had an improved erectile response to sildenafil. Taking into consideration the known influence of the 825C/T polymorphism on vascular risk factors for ED, this investigation was performed to test the hypothesis that the presence of the 825T allele of the GNB3 gene results in an increased risk of vasculogenic ED (VED).
Read the Original
This page is a summary of: G-protein β3 subunit gene 825C/T polymorphism and its association with the presence, severity, and duration of vasculogenic erectile dysfunction, Fertility and Sterility, January 2013, Elsevier, DOI: 10.1016/j.fertnstert.2012.08.033.
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