Mutant p53 as a target for cancer treatment

What is it about?

The review article discusses the emerging drugs for targeting mutant 53

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Why is it important?

Mutant p53 is the most frequent genetic alteration in cancer. It was previously believed to be undruggable. However, in recent years, several compounds have been described that can reactivate mutant p53 to an active form. These compounds are discussed in this Review