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Artificial truncation of the C-terminus of the host protein CPSF6 causes cytoplasmic localization and restricts HIV-1 infection at nuclear entry. Passage of HIV-1 in the presence of truncated CPSF6 led to a single amino acid mutation in capsid that rendered HIV-1 resistant to the restriction. The mutant, N74D HIV-1, uses different host proteins for nuclear entry.

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This page is a summary of: Flexible Use of Nuclear Import Pathways by HIV-1, Cell Host & Microbe, March 2010, Elsevier,
DOI: 10.1016/j.chom.2010.02.007.
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