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Osteocytes - bone cells embedded in the mineralized tissue - are generally thought to control bone adaptation and repair. However, bone marrow cells - including mesenchymal stem cells, preosteoblasts, and many other cells - are mechanosensitive. We showed that isolated mechanical stimulation of this cell population induces bone formation without a canonical osteocyte response.
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This page is a summary of: Bone marrow mechanotransduction in porcine explants alters kinase activation and enhances trabecular bone formation in the absence of osteocyte signaling, Bone, February 2018, Elsevier,
DOI: 10.1016/j.bone.2017.11.007.
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