What is it about?
This study tested a phenolic extract from pennyroyal (Mentha pulegium), a Mediterranean herb, to see if it could help with inflammatory bowel disease (IBD) and lower cancer risk. In mice with induced colitis, the extract reduced colon injury, diarrhea, and inflammation, while also lowering key markers like COX-2 and iNOS. In the lab, the extract slowed the growth and invasion of human colon cancer cells, showing antioxidant, anti-inflammatory, and antiproliferative effects. These findings suggest that pennyroyal phenolics may be a valuable natural source for new therapies that target both gut inflammation and the prevention of colorectal cancer.
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Why is it important?
Chronic inflammation in the gut, such as in IBD, is a major risk factor for colorectal cancer. Current treatments are costly and can have side effects. This research identifies pennyroyal phenolics as a promising, safe, and natural option to calm inflammation and block early cancer-related changes. It strengthens the case for developing plant-based therapies that can complement existing medicine and reduce disease progression.
Perspectives
What excites me here is the way a familiar culinary herb shows powerful effects against two of the most challenging conditions: IBD and colorectal cancer. To me, this research demonstrates how traditional plants, often overlooked beyond food use, can inspire new solutions in modern medicine. It is a reminder that everyday herbs may hold hidden potential to fight disease and improve health outcomes.
Dr. Rosa Direito
Universidade de Lisboa
Read the Original
This page is a summary of: Reduction of inflammation and colon injury by a Pennyroyal phenolic extract in experimental inflammatory bowel disease in mice, Biomedicine & Pharmacotherapy, October 2019, Elsevier,
DOI: 10.1016/j.biopha.2019.109351.
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