What is it about?

Organic chemistry can make molecules that interfere with the binding of cancer-related protein PU.1 to DNA. This approach may ultimately be used to treat a range of cancer types.

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Why is it important?

The more approaches we have to fight cancer, the better, and specialized cancer treatments are becoming more important as broad-spectrum chemotherapy agents lose their function in many cases because of resistance building up.


We show that powerful molecules can be built to help control a member of the ETS superfamily of transcription factors called PU.1. Binding to DNA is tight for these organic compounds. In certain cases, they can block PU.1 binding effectively.

Professor James Keane Bashkin
University of Missouri-St. Louis

Read the Original

This page is a summary of: Modulating DNA by polyamides to regulate transcription factor PU.1-DNA binding interactions, Biochimie, August 2019, Elsevier, DOI: 10.1016/j.biochi.2019.08.009.
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