What is it about?

This is a fascinating story about how transglutaminase is indispensable for normal cell adherence to the underlying substrate and normal movement. The evidence is presented for cell cultures as well as in murine eyes.

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Why is it important?

Transglutaminase is an important player in cell and matrix biology.


Supplementation or activation of TG2 may be a therapeutic strategy in ocular surface disease.

Prof Louis Tong
National University of Singapore

Read the Original

This page is a summary of: Molecular mechanism of transglutaminase-2 in corneal epithelial migration and adhesion, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, June 2013, Elsevier,
DOI: 10.1016/j.bbamcr.2013.02.030.
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