What is it about?
We isolated, characterized, and visualized lipid particles accumulating in human atherosclerotic lesions. The article shows that the lipids come from plasma lipoproteins such as LDL that have been modified in the arterial wall. These lipid particles cause inflammation and can so cause disease progression.
Featured Image
Why is it important?
The data give us information on how atherosclerotic lesions are formed and shows that the accumulating lipids can induce inflammation in the arteries.
Perspectives
There are amazing electron microscopic images of the lipid particle and cholesterol crystals that accumulate in the atherosclerotic lesions.
Dr Katariina Öörni
Wihuri Research Institute
Read the Original
This page is a summary of: Extracellular Lipids Accumulate in Human Carotid Arteries as Distinct Three-Dimensional Structures and Have Proinflammatory Properties, American Journal Of Pathology, February 2018, Elsevier,
DOI: 10.1016/j.ajpath.2017.09.019.
You can read the full text:
Contributors
The following have contributed to this page
