Lipoproteins accumulate in arteries, become modified and cause inflammation
What is it about?
We isolated, characterized, and visualized lipid particles accumulating in human atherosclerotic lesions. The article shows that the lipids come from plasma lipoproteins such as LDL that have been modified in the arterial wall. These lipid particles cause inflammation and can so cause disease progression.
Why is it important?
The data give us information on how atherosclerotic lesions are formed and shows that the accumulating lipids can induce inflammation in the arteries.
The following have contributed to this page: Dr Katariina Öörni and Dr Satu Lehti