Spatial Distributions of Lipids in Atherosclerosis of Human Coronary Arteries Studied by Time-of-Flight Secondary Ion Mass Spectrometry

Satu Lehti, Peter Sjövall, Reijo Käkelä, Mikko I. Mäyränpää, Petri T. Kovanen, Katariina Öörni
  • American Journal Of Pathology, May 2015, Elsevier
  • DOI: 10.1016/j.ajpath.2015.01.026

Lipoprotein-associated lipids accumulate in distinctive domains in atherosclerotic arteries.

What is it about?

We combined a surface analysis method (Secondary Ion Mass Spectrometry, SIMS) to immunohistochemistry in order to visualize lipids that have accumulated in coronary arteries in different stages of atherosclerosis. Cholesterol was found to accumulate differently from triglycerides. Interestingly, also the lipid content of media was altered.

Why is it important?

The different accumulation patterns of triglycerides and cholesterol propose that in addition to LDL, also triglycerice-rich VLDL and chylomicron remnants enter the artery intima and are important in atherosclerosis development.


Dr Satu Lehti
Wihuri Research Institute

Combining a surface analysis to histology gave us an opportunity to see beneath the histology.

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The following have contributed to this page: Dr Katariina Öörni and Dr Satu Lehti