Relationship between calcium mobilization and platelet α- and δ-granule secretion. A role for TRPC6 in thrombin-evoked δ-granule exocytosis

E. Lopez, N. Bermejo, A. Berna-Erro, N. Alonso, G.M. Salido, P.C. Redondo, J.A. Rosado
  • Archives of Biochemistry and Biophysics, November 2015, Elsevier
  • DOI: 10.1016/j.abb.2015.09.012

What is it about?

Activated platelets degranulate to release agents important for primary haemostasis. Intracellular Ca2+ mobilization is essential for α- and δ-granule α-granule secretion occurs rapidly upon platelets stimulation with Exogenous Ca2+ entry is necessary for the exocytosis of δ-granule but not α-granules. Canonical transient receptor potential-6 (TRPC6) function is important for δ-granule secretion.

Read Publication

http://dx.doi.org/10.1016/j.abb.2015.09.012

The following have contributed to this page: Dr Nuria Bermejo