What is it about?

To investigate more effective chemotherapy against hormone refractory prostate cancer (HRPC) with the combination of estramustine (EM), docetaxel, and suramin.

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Why is it important?

Management of this hormone refractory stage of prostate cancer remains a significant challenge to the clinician.


The ultimate goal of a treatment of hormone refractory prostate cancer is the demonstration of prolongation of disease-related survival. The optimal therapy, if any, for HRPC patients with disease progression after hormone therapy is unknown. A relatively well tolerated agent, such as suramin, in combination with EM and docetaxel could be considered testing as moderately effective chemotherapy.

Dr Mohammad Reza Safarinejad
University of Medical Sceices

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This page is a summary of: Combination chemotherapy with docetaxel, estramustine and suramin for hormone refractory prostate cancer, Urologic Oncology Seminars and Original Investigations, March 2005, Elsevier,
DOI: 10.1016/j.urolonc.2004.10.003.
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