What is it about?
To determine the effect of opioid consumption on the serum prostate-specific antigen (PSA) level.
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Why is it important?
Opioids are present in the prostate gland, and in vitro studies have shown that opioid agonists interfere with PSA secretion and decrease the proliferation of prostate cancer cell lines. PSA expression is dramatically influenced by androgens, and an in vitro study has shown that opioids inhibit androgen-induced PSA secretion. In addition to the direct effects on prostatic tissue, opioids have been hypothesized to affect the hypothalamuspituitary-gonadal axis and suppress androgen production. Consequent hypogonadotropic hypogonadism could also alter the serum PSA level. The effect of opioids on the serum PSA level has never been tested in vivo.
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This page is a summary of: Influence of Opioid Consumption on Serum Prostate-specific Antigen Levels in Men Without Clinical Evidence of Prostate Cancer, Urology, July 2012, Elsevier,
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