What is it about?

Paroxysmal, persistent and permanent atrial fibrillation (AF), all significantly increase the stroke risk up to 20% annually. Available data on fibrinolysis in AF are sparse. We hypothesized that inAF patients even on sinus rhythm thromboembolic risk is related to formation of compact plasma fibrin clots resistant to plasmin-mediated lysis.

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Why is it important?

To our knowledge, this study is the first to show tighter clot structure displaying decreased susceptibility to lysis in the patients with sinus rhythm who experienced a short-term AF episode. The study shows that thrombin generation, markers of endothelial injury and platelet activation, are associated with altered fibrin clot properties in patients with AF.


Further studies are necessary to establish whether: (1) Unfavorably altered fibrin clot properties, contributes to thromboembolic complications in AF. (2) Ex-vivo plasma fibrin clot permeability (Ks) and clot lysis time (CLT) may predict increased thrombotic risk in AF

Leszek Drabik
Uniwersytet Jagiellonski w Krakowie

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This page is a summary of: Denser plasma clot formation and impaired fibrinolysis in paroxysmal and persistent atrial fibrillation while on sinus rhythm: Association with thrombin generation, endothelial injury and platelet activation, Thrombosis Research, August 2015, Elsevier,
DOI: 10.1016/j.thromres.2015.05.028.
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