What is it about?

Herein, we developed a novel, enzyme-free electrochemical biosensor that can directly quantify creatinine within complex biological fluids in a highly specific and sensitive manner. This user-friendly and cost-effective device can provide reliable information on creatinine levels using a urine sample.

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Why is it important?

We introduced for the first -time a novel approach to eliminate non-specific signals by using an ionic membrane (termed pseudo proton exchange membrane) which can repel the interferents from reaching the electrode surface. We also verified the accuracy developed sensor with clinically obtained results


A lot of chronic diseases including chronic kidney disease do not show symptoms in their early stages and often have high mortality in the end stages. During my study in Taiwan, I noticed the high prevalence of kidney impairments in the country and the immense capital spent by the government on dialysis centers. I hope that the development of user-friendly biosensors can aid in the routine analysis of at-risk groups and improve their lives.

Dr. Rakesh Kumar Rajkumar
National Taiwan University

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This page is a summary of: Enzymeless electrochemical biosensor platform utilizing Cu2O-Au nanohybrids for point-of-care creatinine testing in complex biological fluids, Sensors and Actuators B Chemical, January 2024, Elsevier,
DOI: 10.1016/j.snb.2023.134787.
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