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We describe a process for the purification of minicircles (MC) obtained from Escherichia coli that features an endonuclease digestion step followed by multimodal chromatography.

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This page is a summary of: Multimodal chromatography of supercoiled minicircles: A closer look into DNA-ligand interactions, Separation and Purification Technology, April 2019, Elsevier,
DOI: 10.1016/j.seppur.2018.11.015.
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