What is it about?

Numerous chemicals are presently implemented in agriculture, including phytohormones or plant growth regulators (PGRs) which are commonly employed. The literature reports various effects of PGR application on living organisms. Nevertheless, significant contradictions between results still exist. Therefore, elucidating the mechanism of toxicity for PGRs and establishing an understanding of structure-toxicity relationships are essential for a more rational design of PGRs. For this purpose, administration of PGRs was carried out orally as it provides a well-established in vivo toxicity model system. The specific tissues were selected because of their significance in degradation and bioactivation involved in the detoxification of PGRs.

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In conclusion, these results suggest that serum marker enzymes, tissue antioxidant markers, and MDA content could provide a means of monitoring the toxicity of compounds like ABA and GA3 (PGRs). Further studies may confirm our findings and facilitate the use of these test results in forthcoming investigations. This test would be valuable in pollution studies and help in comprehending the molecular basis of refractory ABA and GA3 toxicity.


In recent times, there has been a noteworthy surge in the application of plant growth regulators (PGRs) to combat crop loss caused by agricultural pests worldwide. The primary reason behind this upsurge is the ease of application and accurate outcomes attributed to PGRs. At present, ABA and GA3 have been chosen for this study owing to the limited knowledge on their adverse outcomes on higher animals concerning in vivo and oral exposures. There is limited knowledge regarding the biochemical and physiological impacts of the chemical on vertebrates. The data obtained for this study were solely collected at one time point during the experiment.

Van Yüzüncü Yıl University

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This page is a summary of: Influence of subacute and subchronic treatment of abcisic acid and gibberellic acid on serum marker enzymes and erythrocyte and tissue antioxidant defense systems and lipid peroxidation in rats, Pesticide Biochemistry and Physiology, October 2006, Elsevier, DOI: 10.1016/j.pestbp.2006.01.009.
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