What is it about?

We explored the efficacy of selenium and/or or N-acetyl-cysteine for improving semen parameters in infertile men, and the associations among semen quality and the concentrations of selenium and N-acetyl-cysteine in seminal plasma.

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Why is it important?

IT is generally estimated that approximately 10% to 15% of couples have difficulty with conceiving. Globally male factors, such as oligospermia and/or asthenospermia, account for almost half of all infertility cases. Infertility is an important medical and social problem in magnitude and the impact on well-being. Despite many advances in assisted reproductive techniques in the last decade to our knowledge effective medical treatments in infertile men with idiopathic oligo-asthenoteratospermia have yet to be determined.


Given the challenges of using conventional pharmacotherapy to improve and maintain semen parameters in men with idiopathic oligo-asthenospermia, our results support the use of Se and/or NAC as a simple, inexpensive and safe therapy. Further studies are needed to confirm this finding.

Dr Mohammad Reza Safarinejad
University of Medical Sceices

Read the Original

This page is a summary of: Efficacy of Selenium and/or N-Acetyl-Cysteine for Improving Semen Parameters in Infertile Men: A Double-Blind, Placebo Controlled, Randomized Study, The Journal of Urology, February 2009, Wolters Kluwer Health,
DOI: 10.1016/j.juro.2008.10.015.
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